CAR-T cell therapy cost in Israel

CAR-T cell therapy has given hope to many haemato-oncological patients around the world. The new innovative immunotherapy method uses the patient’s own immune system to seek and kill cancer cells. As of 2022, six CAR-T therapies have been approved in the USA (Abecma™ ,Breyanzi™, Kymriah™, Tecartus™, Yescarta™, Carvykti™), and many hospitals around the world offer the cutting-edge treatment. Unfortunately, the treatment’s cost keeps it out of reach for many patients.

Prices of the USA based CAR-T’s vary between $300,000 USD and $500,000 USD, since the patient’s blood needs to be transferred to the USA pharmaceutical company and then transferred back to the country of origin, all under strictly supervised conditions, in order to preserve the freshness and effectiveness of the CAR-T cells.

Other countries have begun to develop their own in-house CAR-T treatments, but to this day (2022), many are still in early stages and without much experience in the complicated procedure and treatment of the therapy’s side effects. (CRS -Cytokine release syndrome- syndrome)

Sheba hospital's CAR- T therapy

Sheba Hospital’s in-house CAR-T therapy has begun operating in 2015 and to this day more than 250 patients have undergone the treatment. In fact, one of the reasons which Sheba hospital was nominated as one of the best 10 hospitals in the world by Newsweek magazine, was the innovative research and medical discoveries done in Sheba’s laboratories.

Lonza’s cocoon system at Sheba hospital

Comparison of CAR-T processes

The entire process is done in-house Blood & cells fly on a long journey overseas
Cell quality is preserved Cell quality affected by the freezing
Suitable for a wide range of diseases Approved for a few diseases
Takes about 10 days Takes 1-2 months
Cost: $100,000-$120,000 USD Cost: $200,000-$500,000 USD (Depending on the country)

Read more about the difference between Sheba's in-house CAR-T therapy and other commercial CAR-T's >>
CAR-T therapy in Sheba hospital -patient review

What does the price of CAR-T therapy in Sheba consist of?

Assessment - Including ambulatory tests: bone scan, pulmonary function, MUGA, laboratory tests, bone marrow biopsy, imaging, CT and ultrasound scans, nuclear medicine, etc. $5,000-$15,000
Pre-CAR T chemotherapy, if needed $5,000-$100,000
CAR-T procedure - including lymphocyte cell collection, Laboratory preparation $35,000
21 days of acute care hospitalization (standard protocol) $31,500
Blood products according to patients’ condition 5-30 $1,390-$8,340
Accommodation cost estimate for 2 months $4000-$10,000

What types of cancer respond to the Car T cell procedure?

CAR-T might be suitable for CD19 positive patients with the following conditions:
  • Acute Lymphocytic Leukemia (ALL), Adult
  • Leukemia (ALL), Child
  • Acute Myelogenous Leukemia (AML)
  • Non-Hodgkin Lymphoma (NHL), Adult and Child
  • Multiple Myeloma
85-90% in young children
80% in teenagers
70% in the entire patient population

Patients from the following countries received Car-T treatment in Sheba hospital:

CAR-T therapy in Sheba hospital, Israel - patient's father review

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